Simulations cannot be more instructive than the data from which they are run. Some of the differences between teams that often decide games cannot be quantified.
After a lot of hand-wringing last weekend, the Buckeyes finally beat the Hoosiers (a physically inferior team) after simply wearing them out. Whether or not you believe that Ohio State's latter efficiency against Indiana was because of improved performance levels or the increasing weariness of their opponent, the real truth could be simply the accurate observation that Indiana almost NEVER beats Ohio State.
I think as others do that the Sooners could have a serious mismatch going against their opponent in the passing game. I wouldn't discount the value of the ground game, though. I'm not convinced that the Buckeyes can close down the run with consistency because their defensive front 7 is built to stop the power rushing game, not a quick and shifty one.
I certainly hope that the Buckeyes aren't able to consistently control the clock via sustained ground attacks. If OU's 3-4 defense can't control their running game, the Sooners probably will lose the game. I'm putting my faith in the coaches and players, and how I believe they will perform.
(Or maybe OU wins because they almost NEVER lose both games of a non-conference home-and-home. It really could be that simple.)